saicar

Also known as Succino-AICAR, succinylaminoimidazolecarboxamide ribose-5'-phosphate, succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5-phosphate, SAICA riboside, Succinylaminoimidazole carboxamide riboside, Phosphoribosylaminoimidazolesuccinocarboxamide

Wikidata facts

Mass: 454.073709

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chemical formula: C₁₃H₁₉N₄O₁₂P
canonical SMILES: C1=NC(=C(N1C2C(C(C(O2)COP(=O)(O)O)O)O)N)C(=O)NC(CC(=O)O)C(=O)O
isomeric SMILES: C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O)N)C(=O)N[C@@H](CC(=O)O)C(=O)O

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{{Chembox | Name = Phosphoribosylaminoimidazolesuccinocarboxamide | Verifiedfields = changed | verifiedrevid = 464385050 | ImageFile = SAICAR.png | ImageFile_Ref = | ImageSize = 200px | SystematicName = PP(2S)-(5-Amino-1-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboxamido)butanedioic acid | OtherNames = SAICAR; 2-[(5-Amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}imidazol-4-yl)formamido]butanedioic acid; N-{[5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid | Section1 = | Section2 = }}

Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) is an intermediate in the formation of purines. The conversion of ATP, L-aspartate, and 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide, ADP, and phosphate by phosphoribosylaminoimidazolesuccinocarboxamide synthetase (SAICAR synthetase) represents the eighth step of de novo purine nucleotide biosynthesis.