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phosphoribosylamine
Sign in to savePhosphoribosylamine (PRA) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine and cobalamin also contain fragments derived from PRA. thumb|left|Phosphoribosyl pyrophosphate (PRPP) It is the product of the enzyme amidophosphoribosyltransferase which attaches ammonia from glutamine to phosphoribosyl pyrophosphate (PRPP) at its anomeric carbon: + → + + PPi The biosynthesis pathway next combines PRA with glycine in a process driven by ATP giving glycineamide ribonucleotide (GAR). The
In the Vinony graph
Within Vinony's link graph, phosphoribosylamine is referenced by 42 other articles, and connects out to nucleotide, deoxyribonucleic acid and International Standard Book Number.
Vinony files it under Amino sugars and Organophosphates.
Its subject is documented across 13 Wikipedia language editions.
Chemical data
- Formula
- C5H12NO7P
- Molecular weight
- 229.13 g/mol
- IUPAC name
- [(2R,3S,4R)-5-amino-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
- SMILES
- C([C@@H]1[C@H]([C@H](C(O1)N)O)O)OP(=O)(O)O
- InChIKey
- SKCBPEVYGOQGJN-SOOFDHNKSA-N
- XLogP
- -6.2
- Polar surface area
- 142 Ų
- H-bond donors
- 5
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 229.035138354
Show 3 more facts
- canonical SMILES
- C(C1C(C(C(O1)N)O)O)OP(=O)(O)O
- chemical formula
- C₅H₁₂NO₇P
- isomeric SMILES
- NC1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Phosphoribosylamine (PRA) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine and cobalamin also contain fragments derived from PRA. thumb|left|Phosphoribosyl pyrophosphate (PRPP) It is the product of the enzyme amidophosphoribosyltransferase which attaches ammonia from glutamine to phosphoribosyl pyrophosphate (PRPP) at its anomeric carbon: + → + + PPi The biosynthesis pathway next combines PRA with glycine in a process driven by ATP giving glycineamide ribonucleotide (GAR). The enzyme phosphoribosylamine—glycine ligase catalyses the reaction forming an amide bond: + + ATP → + ADP + Pi ==See also== 5-Aminoimidazole ribotide Purine metabolism ==References==
Category:Organophosphates Category:Amino sugars
Excerpted from Wikipedia’s “phosphoribosylamine” article, available under the CC BY-SA 4.0 licence.