SECISBP2
Sign in to saveAlso known as SBP2, SECIS binding protein 2
SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.
In the Vinony graph
Within Vinony's link graph, SECISBP2 is referenced by 7 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 9 and Selenoproteins.
Its subject is documented across 7 Wikipedia language editions.
Gene data
SECISBP2- Name
- SECIS binding protein 2
- Type
- protein-coding
- Position
- 89,318,460–89,367,116 (+)
- Aliases
- SBP2, THMA1
- Ensembl
- ENSG00000187742
- RefSeq RNA
- NM_001282688.2, NM_001282689.2, NM_001282690.1, NM_001354696.2, NM_001354697.2
- RefSeq protein
- NP_001269617.1, NP_001269618.1, NP_001269619.1, NP_001341625.1, NP_001341626.1
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SECIS binding protein 2
- Symbol
- SECISBP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:89,318,460-89,367,116
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 11415
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79048
- genomic end
- 89359663
- genomic start
- 89318500
- chromosome
- human chromosome 9
- cytogenetic location
- 9q22.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- See also
- References
- Further reading
SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.
== Function ==
Excerpted from Wikipedia’s “SECISBP2” article, available under the CC BY-SA 4.0 licence.