selfotel
Sign in to saveAlso known as SET755, CGS-19755, CGS19755
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
Wikidata facts
- Mass
- 223.060959
Show 5 more facts
- chemical formula
- C₇H₁₄NO₅P
- isomeric SMILES
- C1CN[C@@H](C[C@@H]1CP(=O)(O)O)C(=O)O
- canonical SMILES
- C1CNC(CC1CP(=O)(O)O)C(=O)O
- World Health Organisation international non-proprietary name
- selfotel
- Commons category
- Selfotel
via Wikidata · CC0
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Article
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- References
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
== References ==