Structure via PubChem · Public domain (PubChem)
سلیسیکلیب
Sign in to saveAlso known as (R)-roscovitine, CYC-202, CYC202, R-roscovitine, roscovitine, (2R)-2-{[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino}butan-1-ol, 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, (2R)-2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-1-butanol
Seliciclib (roscovitine or CYC202) is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that inhibit multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase or state within the cell cycle of treated cells. Seliciclib is being developed by Cyclacel.
Chemical data
- Formula
- C19H26N6O
- Molecular weight
- 354.4 g/mol
- IUPAC name
- (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
- SMILES
- CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3
- InChIKey
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N
- XLogP
- 3.2
- Polar surface area
- 87.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- non-small cell lung carcinoma, neoplasm, pituitary-dependent Cushing's disease, breast cancer
via ChEMBL · EBI
Research
1,571 papers- Treatment of Cushing Disease With Pituitary-Targeting Seliciclib.The Journal of clinical endocrinology and metabolism · 2023
- Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance.Journal of biotechnology · 2015
- Seliciclib in malignancies.Expert opinion on investigational drugs · 2009
- Spatiotemporal control of neutrophil fate to tune inflammation and repair for myocardial infarction therapy.Nature communications · 2024
- Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.International journal of cancer · 2009
via PubMed
Wikidata facts
- Mass
- 354.217
- Has use
- medication
Show 6 more facts
- found in taxon
- Ophioparma ventosa
- chemical formula
- C₁₉H₂₆N₆O
- subject has role
- protein kinase inhibitors
- canonical SMILES
- CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- isomeric SMILES
- CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- World Health Organisation international non-proprietary name
- seliciclib
Sources (2)
via Wikidata · CC0