Structure via PubChem · Public domain (PubChem)
Seliciclib
Sign in to saveAlso known as (R)-roscovitine, CYC-202, CYC202, R-roscovitine, roscovitine, (2R)-2-{[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino}butan-1-ol, 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, (2R)-2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-1-butanol
composto chimico
Chemical data
- Formula
- C19H26N6O
- Molecular weight
- 354.4 g/mol
- IUPAC name
- (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
- SMILES
- CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3
- InChIKey
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N
- XLogP
- 3.2
- Polar surface area
- 87.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- non-small cell lung carcinoma, neoplasm, pituitary-dependent Cushing's disease, breast cancer
via ChEMBL · EBI
Research
1,571 papers- Treatment of Cushing Disease With Pituitary-Targeting Seliciclib.The Journal of clinical endocrinology and metabolism · 2023
- Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance.Journal of biotechnology · 2015
- Seliciclib in malignancies.Expert opinion on investigational drugs · 2009
- Spatiotemporal control of neutrophil fate to tune inflammation and repair for myocardial infarction therapy.Nature communications · 2024
- Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.International journal of cancer · 2009
via PubMed
Wikidata facts
- Mass
- 354.217
- Has use
- medication
Show 6 more facts
- found in taxon
- Ophioparma ventosa
- chemical formula
- C₁₉H₂₆N₆O
- subject has role
- protein kinase inhibitors
- canonical SMILES
- CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- isomeric SMILES
- CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- World Health Organisation international non-proprietary name
- seliciclib
Sources (2)
via Wikidata · CC0