SERPINE2

Also known as GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.

Gene data

SERPINE2

Name: serpin family E member 2
Type: protein-coding
Position: 223,975,045–224,039,688 (−)
Aliases: GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
Ensembl: ENSG00000135919
RefSeq RNA: NM_001136528.2, NM_001136530.1, NM_006216.4, NR_073116.2, XM_005246641.3
RefSeq protein: NP_001130000.1, NP_001130002.1, NP_006207.1, XP_005246698.1, XP_016859819.1

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].