SERPINI1
Sign in to saveAlso known as PI12, neuroserpin, serpin family I member 1, HNS-S2, HNS-S1
Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.
In the Vinony graph
Vinony's link graph records 41 inbound references to SERPINI1, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Vinony links it to 8 Wikipedia language editions.
Gene data
SERPINI1- Name
- serpin family I member 1
- Type
- protein-coding
- Position
- 167,735,065–167,828,461 (+)
- Aliases
- HNS-S1, HNS-S2, PI12, neuroserpin
- Ensembl
- ENSG00000163536
- RefSeq RNA
- NM_001122752.2, NM_005025.5, XM_017006618.3, XM_054346841.1
- RefSeq protein
- NP_001116224.1, NP_005016.1, XP_016862107.1, XP_054202816.1
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
serpin family I member 1
- Symbol
- SERPINI1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:167,735,065-167,828,461
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SERPINI1 PDB 1jjo.png
Show 8 more facts
- HomoloGene ID
- 21045
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5274
- genomic end
- 167825569
- genomic start
- 167453031
- chromosome
- human chromosome 3
- cytogenetic location
- 3q26.1
- expressed in
- Brodmann area 46
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.
It is associated with Familial encephalopathy with neuroserpin inclusion bodies.
Excerpted from Wikipedia’s “SERPINI1” article, available under the CC BY-SA 4.0 licence.