Structure via PubChem · Public domain (PubChem)
SKF-77434
Sign in to saveAlso known as 3-Allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, N-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, SK&F 77434, SKF 77434, SKF-77,434
SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.
Chemical data
- Formula
- C19H21NO2
- Molecular weight
- 295.4 g/mol
- IUPAC name
- 5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
- SMILES
- C=CCN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O
- InChIKey
- QBUVZVXIRYFENV-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 43.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
39 papers- The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats.Brain research · 1992
- Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.The Journal of pharmacology and experimental therapeutics · 2000
- Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434.European journal of pharmacology · 1998
- Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys.Psychopharmacology · 2002
- Differential effects of dopamine D1 and D2 receptor agonists on schedule-controlled behavior of squirrel monkeys.The Journal of pharmacology and experimental therapeutics · 1995
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 295.157
Show 3 more facts
- chemical formula
- C₁₉H₂₁NO₂
- canonical SMILES
- C=CCN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O
- subject has role
- dopamine agonist
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.
==See also== Substituted 3-benzazepine
Excerpted from Wikipedia’s “SKF-77434” article, available under the CC BY-SA 4.0 licence.