Structure via PubChem · Public domain (PubChem)
diphenylpyraline
Sign in to saveAlso known as diphenylpyralamine, 4-(benzhydryloxy)-N-methylpiperidine, 1-methyl-4-hydroxypiperidine benzhydryl ether, 4-(benzhydryloxy)-1-methylpiperidine, 1-methyl-4-piperidyl benzhydryl ether
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.
Chemical data
- Formula
- C19H23NO
- Molecular weight
- 281.4 g/mol
- IUPAC name
- 4-benzhydryloxy-1-methylpiperidine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- allergic disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 281.178
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₉H₂₃NO
- canonical SMILES
- CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3
- World Health Organisation international non-proprietary name
- diphenylpyraline
- defined daily dose
- 10.0
- Commons category
- Diphenylpyraline
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.
==Synthesis== 501px|center|class=skin-invert-image
Excerpted from Wikipedia’s “diphenylpyraline” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
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via Wikidata sitelinks · CC0