SMARCB1
Sign in to saveAlso known as BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.
Gene data
SMARCB1- Name
- SWI/SNF related BAF chromatin remodeling complex subunit B1
- Type
- protein-coding
- Position
- 23,786,931–23,838,009 (+)
- Aliases
- BAF47, CSS3, INI-1, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1
- Ensembl
- ENSG00000099956
- RefSeq RNA
- NM_001007468.3, NM_001317946.2, NM_001362877.2, NM_003073.5
- RefSeq protein
- NP_001007469.1, NP_001304875.1, NP_001349806.1, NP_003064.2
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SWI/SNF related BAF chromatin remodeling complex subunit B1
- Symbol
- SMARCB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:23,786,931-23,838,009
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/6598
- HomoloGene ID
- 2310
- genomic start
- 23786931
- genomic end
- 23838009
- cytogenetic location
- 22q11.23|22q11
Sources (7)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.
== Function ==