spiperone

Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ((JP)) is a typical antipsychotic of the butyrophenone family related to haloperidol. It is approved for clinical use in Japan as a treatment for schizophrenia.

==Pharmacology== ===Pharmacodynamics=== {| class="wikitable floatleft" |+ Spiperone at targets |- ! Receptor !! Ki (nM) !! Notes |- | 5-HT1A || 17.3 || |- | 5-HT1B || 995 || |- | 5-HT1D || 2397 || |- | 5-HT1E || 5051 || |- | 5-HT1F || 3.98 || |- | 5-HT2A || 1.17 || |- | 5-HT2B || 0.8–1114.2 || 0.8 is bovine |- | 5-HT2C || 922.9 || |- | 5-HT3 || >10000 || Rat/other |- | 5-HT5A || 2512 || Mouse |- | 5-HT6 || 1590 || Rat |- | 5-HT7 || 109.8 || |- | α1A || 20.4 || |- | α1B || 3.09 || |- | α1D || 8.32 || |- | D1 || 398.5 || |- | D2 || 0.16 || |- | D3 || 0.34 || |- | D4 || 1.39 || |- | D5 || 4500 || |- | H1 || 272 || |- | σ || 353 || |}