STAT-2

Also known as ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.

In the Vinony graph

Within Vinony's link graph, STAT-2 is referenced by 855 other articles, and connects out to PubMed, cytokine and interferon gamma.

Vinony files it under Gene expression, Genes on human chromosome 12 and Immune system.

Its subject is documented across 10 Wikipedia language editions.

Gene data

STAT2

Name: signal transducer and activator of transcription 2
Type: protein-coding
Position: 56,338,356–56,360,283 (−)
Aliases: IMD44, ISGF-3, P113, PTORCH3, STAT113
Ensembl: ENSG00000170581
RefSeq RNA: NM_001385110.1, NM_001385111.1, NM_001385113.1, NM_001385114.1, NM_001385115.1
RefSeq protein: NP_001372039.1, NP_001372040.1, NP_001372042.1, NP_001372043.1, NP_001372044.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020].