STAT2

Name

signal transducer and activator of transcription 2

Type

protein-coding

Position

56,338,356–56,360,283 (−)

Aliases

IMD44, ISGF-3, P113, PTORCH3, STAT113

Ensembl

ENSG00000170581

RefSeq RNA

NM_001385110.1, NM_001385111.1, NM_001385113.1, NM_001385114.1, NM_001385115.1

RefSeq protein

NP_001372039.1, NP_001372040.1, NP_001372042.1, NP_001372043.1, NP_001372044.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 2

Symbol

STAT2

Biotype

Protein coding

Organism

Homo sapiens

Location

12:56,338,356-56,360,283

Strand

Reverse (−)

Assembly

GRCh38