STAT2

Also known as ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3

gene da espécie Homo sapiens

In the Vinony graph

Vinony's link graph records 855 inbound references to STAT2, and connects out to PubMed, cytokine and interferon gamma.

It sits within the topics Gene expression, Genes on human chromosome 12 and Immune system.

Vinony links it to 10 Wikipedia language editions.

Gene data

STAT2

Name: signal transducer and activator of transcription 2
Type: protein-coding
Position: 56,338,356–56,360,283 (−)
Aliases: IMD44, ISGF-3, P113, PTORCH3, STAT113
Ensembl: ENSG00000170581
RefSeq RNA: NM_001385110.1, NM_001385111.1, NM_001385113.1, NM_001385114.1, NM_001385115.1
RefSeq protein: NP_001372039.1, NP_001372040.1, NP_001372042.1, NP_001372043.1, NP_001372044.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020].