STAT2
Sign in to saveAlso known as ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.
In the Vinony graph
Vinony's link graph records 855 inbound references to STAT2, and connects out to PubMed, cytokine and interferon gamma.
It sits within the topics Gene expression, Genes on human chromosome 12 and Immune system.
Vinony links it to 10 Wikipedia language editions.
Gene data
STAT2- Name
- signal transducer and activator of transcription 2
- Type
- protein-coding
- Position
- 56,338,356–56,360,283 (−)
- Aliases
- IMD44, ISGF-3, P113, PTORCH3, STAT113
- Ensembl
- ENSG00000170581
- RefSeq RNA
- NM_001385110.1, NM_001385111.1, NM_001385113.1, NM_001385114.1, NM_001385115.1
- RefSeq protein
- NP_001372039.1, NP_001372040.1, NP_001372042.1, NP_001372043.1, NP_001372044.1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
signal transducer and activator of transcription 2
- Symbol
- STAT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:56,338,356-56,360,283
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3952
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6773
- genomic end
- 56360167
- genomic start
- 56735381
- chromosome
- human chromosome 12
- cytogenetic location
- 12q13.3
- expressed in
- canal of the cervix
via Wikidata · CC0
Article · Русский
Преобразователь сигнала и активатор транскрипции 2 — белок, который у человека кодируется геном STAT2. Белок, кодируемый этим геном является членом семейства . В ответ на цитокины и факторы роста, члены STAT семьи фосфорилируются связанными с рецепторами киназами, а затем формируют гомо- или гетеродимеры, которые перемещаются в ядро клетки, где они действуют как активаторы транскрипции. В ответ на интерферон (IFN), этот белок образует комплекс с STAT1 и IFN семейством регулирующих факторов белка P48 (ISGF3G), в котором этот белок действует как трансактиватор, но не имеет способности непосредственно связывать ДНК. Адаптер транскрипции Р300/СВР (EP300/CREBBP), как было выявлено, взаимодействует специфически с этим белком и, как полагают, участвует в процессе блокирования ИФН-альфа в ответ на аденовирус.
Abstract from DBpedia / Wikipedia · CC BY-SA