TACSTD2

Also known as EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, tumor-associated calcium signal transducer 2

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene.

In the Vinony graph

Within Vinony's link graph, TACSTD2 is referenced by 12 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 1.

Its subject is documented across 10 Wikipedia language editions.

Gene data

TACSTD2

Name: tumor associated calcium signal transducer 2
Type: protein-coding
Position: 58,575,433–58,577,252 (−)
Aliases: EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2
Ensembl: ENSG00000184292
RefSeq RNA: NM_002353.3
RefSeq protein: NP_002344.2

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009].

Gene Ontology

Biological process

visual perception negative regulation of epithelial cell migration negative regulation of epithelial cell migration regulation of epithelial cell proliferation negative regulation of stress fiber assembly negative regulation of stress fiber assembly ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis

Molecular function

protein binding

Cellular component

extracellular region extracellular region nucleus cytosol plasma membrane plasma membrane plasma membrane bicellular tight junction

via MyGene.info

Gene · Ensembl

tumor associated calcium signal transducer 2

Symbol: TACSTD2
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:58,575,433-58,577,252
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: TACSTD2.png

Show 8 more facts

HomoloGene ID: 1763
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4070
genomic end: 58577252
genomic start: 58575433
chromosome: human chromosome 1
cytogenetic location: 1p32.1
genetic association: gelatinous drop-like corneal dystrophy

Sources (5)

via Wikidata · CC0

~2 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene.

This intronless gene is located at the short arm of chromosome 1 (1p32.1). It encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Excerpted from Wikipedia’s “TACSTD2” article, available under the CC BY-SA 4.0 licence.