Structure via PubChem · Public domain (PubChem)
Tegaserod
Sign in to saveAlso known as HTF919, SDZ-HTF-919, 1-{[(5-Methoxyindol-3-yl)methylene]amino}-3-pentylguanidine, (E)-tegaserod
chemische Verbindung
Chemical data
- Formula
- C16H23N5O
- Molecular weight
- 301.39 g/mol
- IUPAC name
- 1-[(E)-(5-methoxy-1H-indol-3-yl)methylideneamino]-2-pentylguanidine
- SMILES
- CCCCCN=C(N)N/N=C/C1=CNC2=C1C=C(C=C2)OC
- InChIKey
- IKBKZGMPCYNSLU-RGVLZGJSSA-N
- XLogP
- 2.6
- Polar surface area
- 87.8 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2002
- Admin. routes
- oral
- Indications
- gastroesophageal reflux disease, Constipation, dyspepsia
via ChEMBL · EBI
Research
542 papers- Tegaserod for the Treatment of Irritable Bowel Syndrome.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2020
- Tegaserod: What's Old Is New Again.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
- Tegaserod.2006
- Tegaserod.Drugs · 1999
- Tegaserod for Irritable Bowel Syndrome With Constipation in Women Younger Than 65 Years Without Cardiovascular Disease: Pooled Analyses of 4 Controlled Trials.The American journal of gastroenterology · 2021
via PubMed
Wikidata facts
- Subclass of
- indole alkaloid
- Mass
- 301.190260356
- Has use
- medication
Show 10 more facts
- defined daily dose
- 12
- chemical formula
- C₁₆H₂₃N₅O
- canonical SMILES
- CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2
- World Health Organisation international non-proprietary name
- tegaserod
- medical condition treated
- constipation
- NCI Thesaurus ID
- C66583
- subject has role
- serotonin receptor agonists
- Commons category
- Tegaserod
- found in taxon
- Geodia barretti
- isomeric SMILES
- CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12
via Wikidata · CC0
Article · Deutsch
Tegaserod ist ein Arzneistoff zur Behandlung des Reizdarmsyndroms (IBS) mit Verstopfung (Obstipation) bei Frauen. Unter den Handelsnamen Zelnorm (Novartis) wurde es 2002 in den USA zugelassen. Die Wirkung entsteht durch Aktivierung der 5-HT-Rezeptoren (Serotoninagonist).
Abstract from DBpedia / Wikipedia · CC BY-SA