THBS1
Sign in to saveAlso known as THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
protein-coding gene in the species Homo sapiens
Gene data
THBS1- Name
- thrombospondin 1
- Type
- protein-coding
- Position
- 39,580,130–39,599,466 (+)
- Aliases
- THBS, THBS-1, TSP, TSP-1, TSP1
- Ensembl
- ENSG00000137801
- RefSeq RNA
- NM_003246.4, XM_011521971.3, XM_047432980.1, XM_054378685.1, XM_054378686.1
- RefSeq protein
- NP_003237.2, XP_011520273.1, XP_047288936.1, XP_054234660.1, XP_054234661.1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
response to hypoxianegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of endothelial cell proliferationnegative regulation of cell-matrix adhesionnegative regulation of cell-matrix adhesion
Molecular function
Pathways
Rap1 signaling pathway - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Phagosome - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)ECM-receptor interaction - Homo sapiens (human)Malaria - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Proteoglycans in cancer - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
thrombospondin 1
- Symbol
- THBS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:39,580,130-39,599,466
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI