Structure via PubChem · Public domain (PubChem)
تیوتپا
Sign in to saveAlso known as thioTEPA
Thiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.
Chemical data
- Formula
- C6H12N3PS
- Molecular weight
- 189.22 g/mol
- IUPAC name
- tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
- SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- InChIKey
- FOCVUCIESVLUNU-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 41.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1959
- Admin. routes
- parenteral
- Indications
- osteosarcoma, myelodysplastic syndrome, acute lymphoblastic leukemia, acute myeloid leukemia
via ChEMBL · EBI
Research
3,849 papers- Thiotepa.IARC monographs on the evaluation of carcinogenic risks to humans · 1990
- Revisiting intrathecal thiotepa: Efficacy and safety in secondary CNS malignancies.Medical oncology (Northwood, London, England) · 2024
- Thiotepa.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses · 1991
- Thiotepa.Report on carcinogens : carcinogen profiles · 2011
- Thiotepa-induced leukoderma.Archives of dermatology · 1979
via PubMed
Wikidata facts
- Mass
- 189.048955
- Has use
- medication
Show 7 more facts
- chemical formula
- C₆H₁₂N₃PS
- subject has role
- carcinogen
- World Health Organisation international non-proprietary name
- thiotepa
- medical condition treated
- B-cell lymphoma
- canonical SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- Commons category
- Thiotepa
- legal status (medicine)
- boxed warning
via Wikidata · CC0