thrombomodulin
Sign in to saveAlso known as THBD, fetomodulin, CD141 antigen
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
In the Vinony graph
Within Vinony's link graph, thrombomodulin is referenced by 384 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It is catalogued under topics including Clusters of differentiation, Coagulation system and Genes on human chromosome 20.
Its subject is documented across 13 Wikipedia language editions.
Protein · UniProt
Thrombomodulin
- Gene
- THBD
- Organism
- Homo sapiens (Human)
- Length
- 575 aa
- Molecular mass
- 60,329 Da
- Evidence
- 1: Evidence at protein level
Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed:10761923). Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway (PubMed:29323190, PubMed:33836597, PubMed:9395524). Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or an…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
16 registered- TERMINATEDComparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ FailureAssistance Publique - Hôpitaux de Paris · NCT00361725
- NACOMPLETEDSevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.University of Chile · NCT03772054
- COMPLETEDThrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical InfectionsMedical University of Vienna · NCT04356144
- NACOMPLETEDAnticoagulation, Vitamins, and Endothelial FunctionUS Department of Veterans Affairs · NCT00018460
- TERMINATEDEffects of Oxygen on Lung Tissue During AnesthesiaVanderbilt University · NCT00715338
- UNKNOWNThe Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced CoagulopathyThe First Hospital of Jilin University · NCT06379126
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P07204
- cell component
- extracellular space
- found in taxon
- Homo sapiens
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Genetics and structure
- Function
- Interactions
- References
- Further reading
- External links
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
== Genetics and structure ==
Excerpted from Wikipedia’s “thrombomodulin” article, available under the CC BY-SA 4.0 licence.