Structure via PubChem · Public domain (PubChem)
tolmetin
Sign in to saveAlso known as MCN-2559, McN-2559-21-98, Tolectin®, 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid, 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid, 1-Methyl-5-p-toluoylpyrrole-2-acetic acid, tolmetina, Tolmétine
Tolmetin () is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class.
Chemical data
- Formula
- C15H15NO3
- Molecular weight
- 257.28 g/mol
- IUPAC name
- 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid
- SMILES
- CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O
- InChIKey
- UPSPUYADGBWSHF-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 59.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1976
- Admin. routes
- oral
- Indications
- Arthralgia, Myalgia, rheumatic disease
via ChEMBL · EBI
Research
1,472 papers- Tolmetin-induced hemolysis.Transfusion · 1985
- Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.Drugs · 1978
- Tolmetin-induced anaphylactoid reactions.The New England journal of medicine · 1982
- Tolmetin-induced esophageal ulceration.The Annals of pharmacotherapy · 1997
- Protein binding of tolmetin.Clinical pharmacology and therapeutics · 1978
via PubMed
Wikidata facts
- Subclass of
- non-steroidal anti-inflammatory drug
- Mass
- 257.105
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₅H₁₅NO₃
- medical condition treated
- rheumatoid arthritis
- canonical SMILES
- CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O
- World Health Organisation international non-proprietary name
- tolmetin
- subject has role
- non-steroidal anti-inflammatory drug
- Commons category
- Tolmetin
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Clinical usage
- Mechanism of action
- Side effects
- References
Tolmetin () is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class.
Tolmetin was originally approved by the US FDA in 1976. It is available internationally.
Excerpted from Wikipedia’s “tolmetin” article, available under the CC BY-SA 4.0 licence.