Structure via PubChem · Public domain (PubChem)
تراپیدیل
Sign in to saveAlso known as AR-12008, Trapidil
Trapidil is used in the treatment of chronic stable angina pectoris. It is currently marketed in Japan under the brand name Rocornal.
Chemical data
- Formula
- C10H15N5
- Molecular weight
- 205.26 g/mol
- IUPAC name
- N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- SMILES
- CCN(CC)C1=CC(=NC2=NC=NN12)C
- InChIKey
- GSNOZLZNQMLSKJ-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 46.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
330 papers- Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.Frontiers in pharmacology · 2025
- [Trapidil after one year].Minerva cardioangiologica · 1993
- Intrepide; Trapidil eluting stent.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2008
- Trapidil induces osteogenesis by upregulating the signaling of bone morphogenetic proteins.Cellular signalling · 2018
- Trapidil determines the fate of RHF rats through inhibition of ER stress.Archives of pharmacal research · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 205.132746
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₀H₁₅N₅
- canonical SMILES
- CCN(CC)C1=CC(=NC2=NC=NN12)C
- subject has role
- platelet aggregation inhibitors
- has characteristic
- bitterness
- Commons category
- Trapidil
Sources (2)
via Wikidata · CC0