Structure via PubChem · Public domain (PubChem)
trapidil
Sign in to saveAlso known as AR-12008
Trapidil is used in the treatment of chronic stable angina pectoris. It is currently marketed in Japan under the brand name Rocornal.
Chemical data
- Formula
- C10H15N5
- Molecular weight
- 205.26 g/mol
- IUPAC name
- N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- SMILES
- CCN(CC)C1=CC(=NC2=NC=NN12)C
- InChIKey
- GSNOZLZNQMLSKJ-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 46.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
330 papers- Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.Frontiers in pharmacology · 2025
- [Trapidil after one year].Minerva cardioangiologica · 1993
- Intrepide; Trapidil eluting stent.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2008
- Trapidil induces osteogenesis by upregulating the signaling of bone morphogenetic proteins.Cellular signalling · 2018
- Trapidil determines the fate of RHF rats through inhibition of ER stress.Archives of pharmacal research · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 205.132746
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₀H₁₅N₅
- canonical SMILES
- CCN(CC)C1=CC(=NC2=NC=NN12)C
- subject has role
- platelet aggregation inhibitors
- has characteristic
- bitterness
- Commons category
- Trapidil
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Pharmacology
- References
Trapidil is used in the treatment of chronic stable angina pectoris. It is currently marketed in Japan under the brand name Rocornal.
An analog was assigned the codename AR 12-456.
Excerpted from Wikipedia’s “trapidil” article, available under the CC BY-SA 4.0 licence.