proxyphylline

Chemical data

Formula

C10H14N4O3

Molecular weight

238.24 g/mol

IUPAC name

7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione

SMILES

CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O

InChIKey

KYHQZNGJUGFTGR-UHFFFAOYSA-N

XLogP

-0.8

Polar surface area

78.7 Ų

H-bond donors

1

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

Airway obstruction

via ChEMBL · EBI

• Antifungal polybrominated proxyphylline derivative induces Candida albicans calcineurin stress response in Galleria mellonella.Bioorganic & medicinal chemistry letters · 2020
• Biocatalytic hydrogen-transfer to access enantiomerically pure proxyphylline, xanthinol, and diprophylline.Bioorganic chemistry · 2022
• Investigation of the Binary System of Proxyphylline Enantiomers: Structural Resolution and Phase Diagram Determination.Molecular pharmaceutics · 2024
• Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation.Arzneimittel-Forschung · 1983
• Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity.European journal of medicinal chemistry · 2018

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

238.107

via Wikidata · CC0