trifluperidol
Sign in to saveTrifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia. It was discovered at Janssen Pharmaceutica in 1959.
Research
214 papers- Trifluperidol-induced lactation.Canadian Psychiatric Association journal · 1974
- Trifluperidol in Huntington's chorea.Lancet (London, England) · 1968
- TRIFLUPERIDOL: A BUTYROPHENONE DERIVATIVE.The American journal of psychiatry · 1963
- The evolution of the butyrophenones, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines.International review of neurobiology · 1965
- Reappraisal of trifluperidol against Nsp3 as a potential therapeutic for novel COVID-19: a molecular docking and dynamics study.Future virology · 2021
via PubMed
Wikidata facts
- Mass
- 409.166
Show 4 more facts
- Commons category
- Trifluperidol
- chemical formula
- C₂₂H₂₃F₄NO₂
- canonical SMILES
- C1CN(CCC1(C2=CC(=CC=C2)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
- defined daily dose
- 2
Sources (3)
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Article
3 sectionsContents
- Synthesis
- See also
- References
Trifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia. It was discovered at Janssen Pharmaceutica in 1959.
==Synthesis== [[File:Trifluperidol synthesis.svg|class=skin-invert-image|500px|center|thumb|Thieme Patent (claim 9): Precursor: Sila analogue:]]