TRIOBP
Sign in to saveAlso known as DFNB28, TAP68, TARA, dJ37E16.4, HRIHFB2122, TRIO and F-actin binding protein
TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.
Gene data
TRIOBP- Name
- TRIO and F-actin binding protein
- Type
- protein-coding
- Position
- 37,696,983–37,776,581 (+)
- Aliases
- DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4
- Ensembl
- ENSG00000100106
- RefSeq RNA
- NM_001039141.3, NM_007032.5, NM_138632.2
- RefSeq protein
- NP_001034230.1, NP_008963.3, NP_619538.2
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TRIO and F-actin binding protein
- Symbol
- TRIOBP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:37,696,983-37,776,581
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 5104
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11078
- genomic end
- 38172563
- genomic start
- 37697048
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.1
- expressed in
- right coronary artery
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.
This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessive nonsyndromic deafness. Multiple alternatively-spliced transcript variants that would encode different isoforms have been found for this gene, though some transcripts may be subject to nonsense-mediated decay (NMD).
Excerpted from Wikipedia’s “TRIOBP” article, available under the CC BY-SA 4.0 licence.