VCAN
Sign in to saveAlso known as CSPG2, ERVR, GHAP, PG-M, WGN, WGN1, versican
Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.
Gene data
VCAN- Name
- versican
- Type
- protein-coding
- Position
- 83,471,618–83,585,130 (+)
- Aliases
- CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
- Ensembl
- ENSG00000038427
- RefSeq RNA
- NM_001126336.3, NM_001164097.2, NM_001164098.2, NM_004385.5
- RefSeq protein
- NP_001119808.1, NP_001157569.1, NP_001157570.1, NP_004376.2
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
versican
- Symbol
- VCAN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:83,471,618-83,585,130
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~8 min read
Encyclopedic overview
13 sectionsContents
- Structure
- Function
- N-terminus
- Glycosaminoglycan binding region
- C-terminus
- Clinical significance
- Cancer and metastasis
- Lung disorders
- Skin disorders
- Interactions
- References
- Further reading
- External links
Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.
Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure.
Excerpted from Wikipedia’s “VCAN” article, available under the CC BY-SA 4.0 licence.