veralipride
Sign in to saveVeralipride (Agreal, Agradil) is an atypical antipsychotic of the benzamide class. It is used for the treatment of vasomotor symptoms associated with menopause. It is a D2 receptor antagonist and it induces prolactin secretion without any estrogenic or progestagenic effects. It was first authorised for use in 1979. However, Veralipride has never gained approval in the United States.
Chemical data
- Formula
- C17H25N3O5S
- Molecular weight
- 383.5 g/mol
- IUPAC name
- 2,3-dimethoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
via PubChem
Research
109 papers- The safety of veralipride.Expert opinion on drug safety · 2006
- The dopamine D(2) receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms.Chemistry, an Asian journal · 2024
- Actual status of veralipride use.Clinical interventions in aging · 2010
- [Veralipride and menopause].La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1983
- Veralipride-induced acute coronary syndrome unmasking a non-secreting pheochromocytoma.Journal of endocrinological investigation · 2006
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +383.151
Show 1 more fact
- P2868
- antipsychotics
via Wikidata · CC0
Article
2 sectionsContents
- See also
- References
Veralipride (Agreal, Agradil) is an atypical antipsychotic of the benzamide class. It is used for the treatment of vasomotor symptoms associated with menopause. It is a D2 receptor antagonist and it induces prolactin secretion without any estrogenic or progestagenic effects. It was first authorised for use in 1979. However, Veralipride has never gained approval in the United States.
The women who took it, in addition to extra-pyramidal effects, experienced an aggressive form of depression that resulted in death by suicide for some. The Sanofi laboratory, despite knowing its side effects, allowed women to continue taking it for a considerable amount of time. For this reason, its sale was banned in all countries except Mexico, which allowed its sale to continue for at least 15 years.