Structure via PubChem · Public domain (PubChem)
ビンデシン
Sign in to saveAlso known as Compound 112531, 3-(Aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, 3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, Desacetylvinblastine amide
抗悪性腫瘍剤の一つ
Chemical data
- Formula
- C43H55N5O7
- Molecular weight
- 753.9 g/mol
- IUPAC name
- methyl (13S,15S,17S)-13-[(1R,9R,10S,11R,12R,19R)-10-carbamoyl-12-ethyl-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraene-13-carboxylate
- SMILES
- CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
- InChIKey
- HHJUWIANJFBDHT-KOTLKJBCSA-N
- XLogP
- 2.7
- Polar surface area
- 165 Ų
- H-bond donors
- 5
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Research
1,927 papers- Vindesine in the treatment of leukaemia.Leukemia & lymphoma · 1997
- Role of vindesine in induction chemotherapy in locally-advanced non-small-cell lung cancer.Journal of cancer research and clinical oncology · 1998
- Is there a role for vindesine in the treatment of non-small cell lung cancer?Investigational new drugs · 1993
- The role of vindesine in oncology--recommendations after 10 years' experience.Anti-cancer drugs · 1995
- [Vindesine: a new antineoplastic drug].Giornale di clinica medica · 1981
via PubMed
Wikidata facts
- Mass
- 753.410149
- Has use
- medication
Show 5 more facts
- chemical formula
- C₄₃H₅₅N₅O₇
- route of administration
- intravenous infusion and defusion
- Commons category
- Vindesine
- isomeric SMILES
- CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
- canonical SMILES
- CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
via Wikidata · CC0
Article · 日本語
ビンデシン（vindesine）は、化学療法で用いられるビンカアルカロイドである。抗悪性腫瘍剤（抗がん剤）の一種。CAS登録番号53643-48-4。ビンブラスチンの初めての半合成アナログである。 硫酸塩が「フィルデシン」という商品名で発売されている。VDSという略号で表されることがある。
Abstract from DBpedia / Wikipedia · CC BY-SA