vindesine
Sign in to saveAlso known as Compound 112531, 3-(Aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, 3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, Desacetylvinblastine amide
Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural (e.g. vinblastine and vincristine) and semisynthetic vinca alkaloids (e.g. vinorelbine and vinflunine) derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such a
Research
1,927 papers- Vindesine in the treatment of leukaemia.Leukemia & lymphoma · 1997
- Role of vindesine in induction chemotherapy in locally-advanced non-small-cell lung cancer.Journal of cancer research and clinical oncology · 1998
- Is there a role for vindesine in the treatment of non-small cell lung cancer?Investigational new drugs · 1993
- The role of vindesine in oncology--recommendations after 10 years' experience.Anti-cancer drugs · 1995
- [Vindesine: a new antineoplastic drug].Giornale di clinica medica · 1981
via PubMed
Wikidata facts
- Mass
- 753.410149
Show 4 more facts
- chemical formula
- C₄₃H₅₅N₅O₇
- Commons category
- Vindesine
- isomeric SMILES
- CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
- canonical SMILES
- CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
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Article
1 sectionsContents
- References
Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural (e.g. vinblastine and vincristine) and semisynthetic vinca alkaloids (e.g. vinorelbine and vinflunine) derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.
== References ==