Vindesin

Also known as Compound 112531, 3-(Aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, 3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine, Desacetylvinblastine amide

Arzneistoff

In the Vinony graph

Vinony's link graph records 284 inbound references to Vindesin, and connects out to tiazofurin, liver and medication.

Vinony files it under Chemical articles with multiple CAS registry numbers, Chemicals using indexlabels and Drugs with non-standard legal status.

Vinony links it to 17 Wikipedia language editions.

Chemical data

Formula: C43H55N5O7
Molecular weight: 753.9 g/mol
IUPAC name: methyl (13S,15S,17S)-13-[(1R,9R,10S,11R,12R,19R)-10-carbamoyl-12-ethyl-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraene-13-carboxylate
SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
InChIKey: HHJUWIANJFBDHT-KOTLKJBCSA-N
XLogP: 2.7
Polar surface area: 165 Å²
H-bond donors: 5
H-bond acceptors: 10
Formal charge: 0

via PubChem

Research

1,927 papers

Vindesine in the treatment of leukaemia.Leukemia & lymphoma · 1997
Role of vindesine in induction chemotherapy in locally-advanced non-small-cell lung cancer.Journal of cancer research and clinical oncology · 1998
Is there a role for vindesine in the treatment of non-small cell lung cancer?Investigational new drugs · 1993
The role of vindesine in oncology--recommendations after 10 years' experience.Anti-cancer drugs · 1995
[Vindesine: a new antineoplastic drug].Giornale di clinica medica · 1981

via PubMed

Wikidata facts

Mass: 753.410149
Has use: medication

Show 5 more facts

chemical formula: C₄₃H₅₅N₅O₇
route of administration: intravenous infusion and defusion
Commons category: Vindesine
isomeric SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
canonical SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O

Sources (3)

via Wikidata · CC0

Article · Deutsch

Vindesin ist ein Arzneistoff, der sich vom Vinblastin, einem Alkaloid aus der Pflanze Rosafarbene Catharanthe (Catharanthus roseus, frühere Bezeichnung Vinca rosea), ableitet. Es ist eine weißliche amorphe Substanz und wird als Chemotherapeutikum zur Behandlung von Krebserkrankungen eingesetzt. Vindesin ist ein Zytostatikum aus der Gruppe der Mitose-Hemmer.

Abstract from DBpedia / Wikipedia · CC BY-SA