WBP2
Sign in to saveAlso known as WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.
In the Vinony graph
Within Vinony's link graph, WBP2 is referenced by 2 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It sits within the topics Genes mutated in mice and Genes on human chromosome 17.
Its subject is documented across 5 Wikipedia language editions.
Gene data
WBP2- Name
- WW domain binding protein 2
- Type
- protein-coding
- Position
- 75,845,699–75,856,507 (−)
- Aliases
- DFNB107, GRAMD6, WBP-2
- Ensembl
- ENSG00000132471
- RefSeq RNA
- NM_001330499.2, NM_001348170.1, NM_012478.4, XM_047435712.1, XM_054315634.1
- RefSeq protein
- NP_001317428.1, NP_001335099.1, NP_036610.2, XP_047291668.1, XP_054171609.1
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
WW domain binding protein 2
- Symbol
- WBP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:75,845,699-75,856,507
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 32160
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23558
- genomic end
- 73852588
- genomic start
- 73841780
- chromosome
- human chromosome 17
- cytogenetic location
- 17q25.1
- expressed in
- anterior cingulate cortex
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.
Excerpted from Wikipedia’s “WBP2” article, available under the CC BY-SA 4.0 licence.