Genes on human chromosome 12

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.

Decorin is a protein that in humans is encoded by the DCN gene.

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.

Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.

class of enzymes

Taste receptor, type 2, member 42 is a protein that in humans is encoded by the TAS2R42 gene.

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene. The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides, secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene.

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.

Dual specificity phosphatase 6 (DUSP6) is a phosphatase enzyme that is encoded by the DUSP6 gene in humans.

protein-coding gene in the species Homo sapiens

Protein LMBR1L is a protein that in humans is encoded by the LMBR1L gene.

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

protein-coding gene in the species Homo sapiens

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.

protein-coding gene in the species Homo sapiens

Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

enzyme class, includes alll types of glycogen/starch synthases

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene. It is an EF-Ts homolog.

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.

HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes. Mutations in the HNF1A gene have been known to cause diabetes. The HNF1A gene also contains a SNP associated with increased risk of coronary artery disease.

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.

WNT1 is a gene that encodes the WNT1 protein. It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals. WNT1 was previously known as INT1 in mammals and Wg (or "wingless") in Drosophila. In 1987, it was discovered that they were the same gene (i.e. they were homologous), and the gene was subsequently renamed WNT1 as a portmanteau of wingless and int-1.

protein-coding gene in the species Homo sapiens

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.

protein-coding gene in the species Homo sapiens

RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene.

protein-coding gene in the species Homo sapiens

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. The receptor was discovered in 1987.

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.

C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene.

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.

protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 1 (VAMP1) is a protein that in humans is encoded by the VAMP1 gene.

CAP-Gly domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.

C-type lectin domain family 1 member B (also termed CLEC-1b, C-type lectin-like receptor 2, CLEC-2, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B, CLEC1B, activation-induced C-type lectin, AICL, and 1810061I13Rik) is a cell surface receptor protein. It binds certain biomolecules that act as ligands that when bound to the CLEC-1b expressed by cells stimulates certain functions in these cells. The human CLEC-1b receptor is encoded by the CLEC1B gene which is located on the short (i.e., "p")-arm of chromosome 12 at region 1, band 3, sub-band 1 to sub-band 2 (position not

protein-coding gene in the species Homo sapiens

Ras association domain-containing protein 8 is a protein that in humans is encoded by the RASSF8 gene.

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.

Mucin-like protein 1 is a protein that in humans is encoded by the MUCL1 gene.

protein-coding gene in the species Homo sapiens

Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene. This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

protein-coding gene in the species Homo sapiens

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.

mammalian protein found in Homo sapiens

protein-coding gene

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.