CLEC12A
Sign in to saveAlso known as CLL-1, CLL1, DCAL-2, MICL, CD371, C-type lectin domain family 12 member A
C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.
In the Vinony graph
Within Vinony's link graph, CLEC12A is referenced by 6 other articles, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It sits within the topics C-type lectins and Genes on human chromosome 12.
Its subject is documented across 7 Wikipedia language editions.
Gene data
CLEC12A- Name
- C-type lectin domain family 12 member A
- Type
- protein-coding
- Position
- 9,951,261–9,996,102 (+)
- Aliases
- CD371, CLL-1, CLL1, DCAL-2, MICL, hKLRL1
- Ensembl
- ENSG00000172322
- RefSeq RNA
- NM_001207010.2, NM_001300730.2, NM_138337.6, NM_201623.4, NM_201625.1
- RefSeq protein
- NP_001193939.1, NP_001287659.1, NP_612210.4, NP_963917.2, XP_005253381.1
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
C-type lectin domain family 12 member A
- Symbol
- CLEC12A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:9,951,261-9,996,102
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 51378
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/160364
- genomic end
- 10148293
- genomic start
- 10103915
- chromosome
- human chromosome 12
- cytogenetic location
- 12p13.31
- expressed in
- testicle
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Use in therapy
- References
- Further reading
- External links
C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Excerpted from Wikipedia’s “CLEC12A” article, available under the CC BY-SA 4.0 licence.