Structure via PubChem · Public domain (PubChem)
1-methyltryptophan
Sign in to saveAlso known as N-methyl-DL-tryptophan, N-methyltryptophan, 1-methyl-DL-tryptophan
1-Methyltryptophan is a chemical compound that is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO or INDO ). It is a chiral compound that can exist as both - and -enantiomers.
Chemical data
- Formula
- C12H14N2O2
- Molecular weight
- 218.25 g/mol
- IUPAC name
- 2-amino-3-(1-methylindol-3-yl)propanoic acid
- SMILES
- CN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
- InChIKey
- ZADWXFSZEAPBJS-UHFFFAOYSA-N
- XLogP
- -1.3
- Polar surface area
- 68.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 218.105528
Show 3 more facts
- chemical formula
- C₁₂H₁₄N₂O₂
- canonical SMILES
- CN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
- found in taxon
- Aspergillus fumigatus
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
1-Methyltryptophan is a chemical compound that is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO or INDO ). It is a chiral compound that can exist as both - and -enantiomers.
The -isomer (-1MT) inhibits IDO weakly but also serves as an enzyme substrate.
Excerpted from Wikipedia’s “1-methyltryptophan” article, available under the CC BY-SA 4.0 licence.