11-deoxycortisol

Also known as cortodoxone, (2R,10R,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one, 17-Hydroxy-11-deoxycorticosterone, 11-Deoxy-17-hydroxy-Corticosterone, Reichstein'S substance S, 11-Dioxy-Cortisol, Reichstein'S compound S, 11-Deoxy-17-hydroxycorticosterone

11-Deoxycortisol, also known as cortodoxone (INN), cortexolone as well as 17α,21-dihydroxyprogesterone or 17α,21-dihydroxypregn-4-ene-3,20-dione, is an endogenous glucocorticoid steroid hormone, and a metabolic intermediate toward cortisol. It was first described by Tadeusz Reichstein in 1938 as Substance S, thus has also been referred to as '''Reichstein's Substance S or Compound S'''.

Research

1,684 papers

11-deoxycortisol positively correlates with T cell immune traits in physiological conditions.EBioMedicine · 2024
[11-Deoxycortisol].Nihon rinsho. Japanese journal of clinical medicine · 2005
[11-Deoxycortisol].Nihon rinsho. Japanese journal of clinical medicine · 1995
[11-deoxycortisol and 21-deoxycortisol].Nihon rinsho. Japanese journal of clinical medicine · 1999
11-deoxycortisol is a corticosteroid hormone in the lamprey.Proceedings of the National Academy of Sciences of the United States of America · 2010

via PubMed

Wikidata facts

Mass: 346.214409

Show 5 more facts

chemical formula: C₂₁H₃₀O₄
canonical SMILES: CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C
isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
Commons category: Cortodoxone
melting point: 208

Sources (4)

via Wikidata · CC0

~8 min read