Structure via PubChem · Public domain (PubChem)
prednicarbate
Sign in to saveAlso known as Dermatop®, Hoe 777, Hoe-777, S-770777
Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology; however, their tendency to produce side-effects has caused the need to search for new preparations.
Chemical data
- Formula
- C27H36O8
- Molecular weight
- 488.6 g/mol
- IUPAC name
- [2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
- SMILES
- CCC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)OC(=O)OCC
- InChIKey
- FNPXMHRZILFCKX-KAJVQRHHSA-N
- XLogP
- 4.2
- Polar surface area
- 116 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1991
- Admin. routes
- topical
- Indications
- psoriasis, tinea pedis, Eczematoid dermatitis, candidiasis
via ChEMBL · EBI
Research
142 papersvia PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 488.241018
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₇H₃₆O₈
- medical condition treated
- inflammation
- canonical SMILES
- CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)OC(=O)OCC
- isomeric SMILES
- CCC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)OC(=O)OCC
- subject has role
- glucocorticoid
- Commons category
- Prednicarbate
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 396722627 | IUPAC_name = 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate | image = Prednicarbate.png | image_class = skin-invert-image | width = 250px
| tradename = | Drugs.com = | MedlinePlus = a604021 | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Topical
Excerpted from Wikipedia’s “prednicarbate” article, available under the CC BY-SA 4.0 licence.