Structure via PubChem · Public domain (PubChem)
difluprednate
Sign in to saveAlso known as DFBA, Durezol®, W-6309, Difluoroprednisolone butyrate acetate
Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.
In the Vinony graph
Within Vinony's link graph, difluprednate is referenced by 273 other articles, and connects out to mometasone furoate, fludrocortisone and ulipristal acetate.
Vinony files it under Acetate esters, Butyrate esters and Corticosteroid esters.
Its subject is documented across 12 Wikipedia language editions.
Chemical data
- Formula
- C27H34F2O7
- Molecular weight
- 508.5 g/mol
- IUPAC name
- [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
- SMILES
- CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
- InChIKey
- WYQPLTPSGFELIB-JTQPXKBDSA-N
- XLogP
- 3.4
- Polar surface area
- 107 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- topical
- Indications
- dry eye syndrome, anterior uveitis, inflammation, uveitis
via ChEMBL · EBI
Research
193 papers- Difluprednate.2006
- Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis.BMJ open · 2019
- Difluprednate for inflammatory eye disorders.Drugs of today (Barcelona, Spain : 1998) · 2011
- Outcomes of difluprednate treatment for corneal graft rejection.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2020
- Effectiveness of difluprednate in addition to systemic therapy for the treatment of anterior scleritis.The British journal of ophthalmology · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 508.227
- Manufacturer
- Novartis
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₇H₃₄F₂O₇
- subject has role
- glucocorticoid
- medical condition treated
- eye disease
- canonical SMILES
- CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
- isomeric SMILES
- CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
- Commons category
- Difluprednate
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Medical uses
- Clinical trials
- References
Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.
It was approved for medical use in the United States in June 2008. It is available as a generic medication.
Excerpted from Wikipedia’s “difluprednate” article, available under the CC BY-SA 4.0 licence.