desoximetasone

Also known as A-41-304, HOE-304, R-2113, Topicort®, desoxymethasone, 9alpha-fluoro-16alpha-methyl-Delta(1)-corticosterone, (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Desoximetasone is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation. Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.

Chemical data

Formula: C22H29FO4
Molecular weight: 376.5 g/mol
IUPAC name: (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C
InChIKey: VWVSBHGCDBMOOT-IIEHVVJPSA-N
XLogP: 2.3
Polar surface area: 74.6 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1977
Admin. routes: topical
Indications: psoriasis, skin disease, psoriasis vulgaris

via ChEMBL · EBI

Research

128 papers

Desoximetasone.2006
Desoximetasone 0.25% Spray for the Relief of Scaling in Adults With Plaque Psoriasis.Journal of drugs in dermatology : JDD · 2015
A Comparative Evaluation of Desoximetasone Cream and Ointment Formulations Using Experiments and In Silico Modeling.International journal of molecular sciences · 2023
Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis.Cutis · 2006
A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy.Pharmaceutics · 2023

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Wikidata facts

Mass: 376.205
Has use: medication

Show 6 more facts

medical condition treated: psoriasis
chemical formula: C₂₂H₂₉FO₄
canonical SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)CO)C)O)F)C
isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C
World Health Organisation international non-proprietary name: desoximetasone
subject has role: glucocorticoid

Sources (3)

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Encyclopedic overview

4 sections

Contents

Usage
See also
References
External links

Three brand name products are available (availability depending on country): Topicort Emollient Cream (0.25% desoximetasone) Topicort LP Emollient Cream (0.05% desoximetasone) Topisolone Cream (0.25% desoximetasone)

Excerpted from Wikipedia’s “desoximetasone” article, available under the CC BY-SA 4.0 licence.

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