aceclidine
Sign in to saveAceclidine is a parasympathomimetic cholinergic drug that functions as a muscarinic acetylcholine receptor agonist. It is used in ophthalmology as a miotic agent to constrict the pupil. Historically used in Europe for the treatment of glaucoma, aceclidine received its first U.S. approval in 2025 under the brand name Vizz as a topical eye drop for the correction of presbyopia. Its mechanism of action produces pupil contraction with a relatively minimal effect on the ciliary muscle, which improves near visual acuity through a "pinhole" depth-of-field effect without inducing significant
Key facts
- Drug.image
- Aceclidine.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of aceclidine
- Drug.width
- 140
- Drug.image2
- Aceclidine 3D ball.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 175
- Drug.alt2
- Ball-and-stick model of the aceclidine molecule
- Drug.DailyMedID
- Aceclidine
- Drug.routes_of_administration
- Topical (ophthalmic solution)
- Drug.ATC_prefix
- S01
- Drug.ATC_suffix
- EB08
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.CAS_number
- 827-61-2
- Drug.CAS_number2
- 6109-70-2
- Drug.PubChem
- 1979
- Drug.ChemSpiderID
- 1902
via Wikipedia infobox
Research
111 papers- Aceclidine Hydrochloride.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026
- Aceclidine (Vizz) for presbyopia.The Medical letter on drugs and therapeutics · 2025
- FDA approval of aceclidine (Vizz): a new chapter in nonsurgical presbyopia management.Annals of medicine and surgery (2012) · 2025
- Beyond glasses: FDA approval of VIZZ (aceclidine) transforming presbyopia management.Annals of medicine and surgery (2012) · 2026
- [Aceclidine in the treatment of glaucoma].Oftalmologicheskii zhurnal · 1967
via PubMed
Wikidata facts
- Mass
- 169.11
Show 3 more facts
- chemical formula
- C₉H₁₅NO₂
- canonical SMILES
- CC(=O)OC1CN2CCC1CC2
- Commons category
- Aceclidine
Sources (2)
via Wikidata · CC0
~6 min read
Article
11 sectionsContents
- Medical uses
- Glaucoma
- Presbyopia
- Pharmacology
- Pharmacokinetics
- Mechanism of action
- Chemistry
- History
- Research
- References
- External links
Aceclidine is a parasympathomimetic cholinergic drug that functions as a muscarinic acetylcholine receptor agonist. It is used in ophthalmology as a miotic agent to constrict the pupil. Historically used in Europe for the treatment of glaucoma, aceclidine received its first U.S. approval in 2025 under the brand name Vizz as a topical eye drop for the correction of presbyopia. Its mechanism of action produces pupil contraction with a relatively minimal effect on the ciliary muscle, which improves near visual acuity through a "pinhole" depth-of-field effect without inducing significant accommodative spasm.
== Medical uses ==