Structure via PubChem · Public domain (PubChem)
adimolol
Sign in to saveAdimolol (developmental code name MEN-935) is antihypertensive agent which acts as a non-selective α1-, α2-, and β-adrenergic receptor antagonist.
Chemical data
- Formula
- C25H29N3O3
- Molecular weight
- 419.5 g/mol
- IUPAC name
- 3-[3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]-3-methylbutyl]-1H-benzimidazol-2-one
- SMILES
- CC(C)(CCN1C2=CC=CC=C2NC1=O)NCC(COC3=CC=CC4=CC=CC=C43)O
- InChIKey
- YWRIUGFSIQMHJK-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 73.8 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 419.221
Show 2 more facts
- chemical formula
- C₂₅H₂₉N₃O₃
- canonical SMILES
- CC(C)(CCN1C2=CC=CC=C2NC1=O)NCC(COC3=CC=CC4=CC=CC=C43)O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Adimolol (developmental code name MEN-935) is antihypertensive agent which acts as a non-selective α1-, α2-, and β-adrenergic receptor antagonist.
==Synthesis== The reaction between 1-naphthyl glycidyl ether (1) and 3-(3-amino-3-methylbutyl)-1H-benzimidazol-2-one (2) gives adimolol (3). thumb|left|500px|class=skin-invert-image|Synthesis of adimolol
Excerpted from Wikipedia’s “adimolol” article, available under the CC BY-SA 4.0 licence.