ADORA3

Also known as A3AR, AD026, bA552M11.5, adenosine A3 receptor

protein-coding gene in the species Homo sapiens

Gene data

ADORA3

Name: adenosine A3 receptor
Type: protein-coding
Position: 111,499,429–111,503,633 (−)
Aliases: A3AR
Ensembl: ENSG00000282608
RefSeq RNA: NM_000677.4, NM_001302678.2, NM_001302679.2
RefSeq protein: NP_000668.1, NP_001289607.1, NP_001289608.1

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].