MAS1
Sign in to saveAlso known as MAS, MGRA, MAS1 proto-oncogene, G protein-coupled receptor
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogen
In the Vinony graph
Vinony's link graph records 659 inbound references to MAS1, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
Vinony files it under Genes on human chromosome 6 and G protein-coupled receptors.
Vinony links it to 5 Wikipedia language editions.
Gene data
MAS1- Name
- MAS1 proto-oncogene, G protein-coupled receptor
- Type
- protein-coding
- Position
- 159,830,066–159,917,447 (+)
- Aliases
- MAS, MGRA
- Ensembl
- ENSG00000130368
- RefSeq RNA
- NM_001366704.2, NM_002377.4, XM_047418776.1, XM_054355443.1
- RefSeq protein
- NP_001353633.1, NP_002368.1, XP_047274732.1, XP_054211418.1
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
MAS1 proto-oncogene, G protein-coupled receptor
- Symbol
- MAS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:159,830,066-159,917,447
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1782
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4142
- genomic end
- 159917447
- genomic start
- 159890988
- chromosome
- human chromosome 6
- cytogenetic location
- 6q25.3
- expressed in
- lymph node
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
Agonists of the receptor include angiotensin (1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).
Excerpted from Wikipedia’s “MAS1” article, available under the CC BY-SA 4.0 licence.