MAS1
Sign in to saveAlso known as MAS, MGRA, MAS1 proto-oncogene, G protein-coupled receptor
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogen
Gene data
MAS1- Name
- MAS1 proto-oncogene, G protein-coupled receptor
- Type
- protein-coding
- Aliases
- MAS, MGRA
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].
via MyGene.info
Gene · Ensembl
MAS1 proto-oncogene, G protein-coupled receptor
- Symbol
- MAS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:159,830,066-159,917,447
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1782
- exact match
- identifiers.org/ncbigene/4142
- genomic end
- 159917447
- genomic start
- 159890988
- cytogenetic location
- 6q25.3
Sources (4)
via Wikidata · CC0
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Article
3 sectionsContents
- See also
- References
- Further reading
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
Agonists of the receptor include angiotensin (1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).