MYO3A
Sign in to saveAlso known as myosin IIIA, DFNB30
Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.
Gene data
MYO3A- Name
- myosin IIIA
- Type
- protein-coding
- Position
- 25,934,198–26,212,533 (+)
- Aliases
- DFNA90, DFNB30
- Ensembl
- ENSG00000095777
- RefSeq RNA
- NM_001368265.1, NM_017433.5, XM_011519498.3, XM_011519499.2, XM_011519500.3
- RefSeq protein
- NP_001355194.1, NP_059129.3, XP_011517800.1, XP_011517801.1, XP_011517802.1
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
myosin IIIA
- Symbol
- MYO3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:25,934,198-26,212,533
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.
Excerpted from Wikipedia’s “MYO3A” article, available under the CC BY-SA 4.0 licence.