anipamil

Anipamil is a calcium channel blocker, specifically of the phenylalkylamine type. This type is separate from its more common cousin Dihydropyridine. Anipamil is an analog of the more common drug verapamil, which is the most common type of phenylalkylamine style calcium channel blocker. Anipamil has been shown to be a more effective antiarrhythmic medication than verapamil because it does not cause hypertension as seen in verapamil. It is able to do this by bonding to the myocardium tighter than verapamil.

== Study of Effects in Rabbits == Anipamil is used to prevent the thickening of aortic muscles in rabbits with hypertension . A study was done by the American Journal of Hypertension to understand the effects anipamil may have on the smooth muscle cell in hypertensive rabbits. After using monoclonal antimyosin antibodies to recognize smooth muscle, nonmuscle myosin heavy chains and identify various aortic smooth muscle types, twenty four rabbits with hypertension were studied over a period of 2.5-4 months. The rabbits were split into two groups of 12, and six rabbits from each group received a 40 mg oral dose of anipamil daily while the remaining received an oral placebo daily. Cryosections of primary and secondary smooth aortic muscle were then taken for morphometry and immunocytochemical studies to understand the potential change in phenotype after the addition of anipamil. The study revealed that smooth aortic muscle treated with anipamil demonstrates less thickening of the muscle and an increase in differentiated cell phenotype . The results of this study showed anipamil has a direct effect on smooth muscle cell phenotypes .