BACE2

Name

beta-secretase 2

Type

protein-coding

Position

41,167,775–41,282,530 (+)

Aliases

AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP

Ensembl

ENSG00000182240

RefSeq RNA

NM_012105.5, NM_138991.3, NM_138992.3, XM_017028314.2, XM_054324423.1

RefSeq protein

NP_036237.2, NP_620476.1, NP_620477.1, XP_016883803.1, XP_054180398.1

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

beta-secretase 2

Symbol

BACE2

Biotype

Protein coding

Organism

Homo sapiens

Location

21:41,167,775-41,282,530

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein BACE2 PDB 2ewy.png

via Wikidata · CC0