Structure via PubChem · Public domain (PubChem)
bambuterol
Sign in to saveAlso known as Bambec®, Oxeol®, terbutaline bis(dimethylcarbamate), terbutaline bisdimethylcarbamate, (+-)-5-(2-(tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate), Bambuterolum, bambutérol, (±)-5-(2-(tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate)
Bambuterol (INN) is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Commercially, the AstraZeneca pharmaceutical company produces and markets bambuterol as Bambec and Oxeol.
Chemical data
- Formula
- C18H29N3O5
- Molecular weight
- 367.4 g/mol
- IUPAC name
- [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
- SMILES
- CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O
- InChIKey
- ANZXOIAKUNOVQU-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 91.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Airway obstruction, pulmonary arterial hypertension
via ChEMBL · EBI
Research
197 papers- Rivastigmine-Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors.Molecules (Basel, Switzerland) · 2023
- Clinical pharmacokinetics of bambuterol.Clinical pharmacokinetics · 1996
- Mechanism of action of bambuterol: a beta-agonist prodrug with sustained lung affinity.Agents and actions. Supplements · 1991
- [Bambuterol].Ugeskrift for laeger · 1992
- (R)-Bambuterol attenuates DSS-induced chronic colitis by suppressing inflammation, repairing intestinal barrier, and modulating gut microbiota and serum metabolomic profile.European journal of pharmacology · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 367.210721
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₈H₂₉N₃O₅
- canonical SMILES
- CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O
- defined daily dose
- 20
- World Health Organisation international non-proprietary name
- bambuterol
- subject has role
- bronchodilator
- medical condition treated
- asthma
- physically interacts with
- butyrylcholinesterase
- Commons category
- Bambuterol
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Indications
- Contraindications
- Adverse effects
- Interactions
- Synthesis
- References
Bambuterol (INN) is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Commercially, the AstraZeneca pharmaceutical company produces and markets bambuterol as Bambec and Oxeol.
It is not available in the U.S.
Excerpted from Wikipedia’s “bambuterol” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 11 languages
via Wikidata sitelinks · CC0