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Bemesetron
Sign in to saveBemesetron (MDL-72222) is a drug which acts as an antagonist at the 5HT3 receptor. It has antiemetic effects comparable to metoclopramide, however it is not used clinically, instead its main application is in scientific research studying the involvement of the 5HT3 receptor in the actions of drugs of abuse.
Chemical data
- Formula
- C15H17Cl2NO2
- Molecular weight
- 314.2 g/mol
- IUPAC name
- [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3,5-dichlorobenzoate
- SMILES
- CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CC(=CC(=C3)Cl)Cl
- InChIKey
- MNJNPLVXBISNSX-PBWFPOADSA-N
- XLogP
- 4.2
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
226 papers- Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice.Neuropharmacology · 1995
- Dual cooperative allosteric modulation of binding to ionotropic glycine receptors.Neuropharmacology · 2002
- Characterization of desamino-5-[125I]iodo-3-methoxy-zacopride ([125I]MIZAC) binding to 5-HT3 receptors in the rat brain.Progress in neuro-psychopharmacology & biological psychiatry · 1998
- An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture.British journal of pharmacology · 1993
- 5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.Psychopharmacology · 1995
via PubMed
Wikidata facts
- Mass
- 313.063634144
Show 4 more facts
- chemical formula
- C₁₅H₁₇Cl₂NO₂
- canonical SMILES
- CN1C2CCC1CC(C2)OC(=O)C3=CC(=CC(=C3)Cl)Cl
- subject has role
- serotonin antagonist
- isomeric SMILES
- CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c3cc(cc(c3)Cl)Cl
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Bemesetron (MDL-72222) is a drug which acts as an antagonist at the 5HT3 receptor. It has antiemetic effects comparable to metoclopramide, however it is not used clinically, instead its main application is in scientific research studying the involvement of the 5HT3 receptor in the actions of drugs of abuse.
==See also== Tropanserin Tropisetron Zatosetron Ricasetron Granisetron
Excerpted from Wikipedia’s “Bemesetron” article, available under the CC BY-SA 4.0 licence.