Bithionol

Also known as Bithionol sulfide, Bis(3,5-dichloro-2-hydroxyphenyl) sulfide, 2-Hydroxy-3,5-dichlorophenyl sulfide, 2,2'-Thiobis(4,6-dichlorophenol), 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide, Bithin, 2,2'-Thiobis[4,6-dichlorophenol], 2,2'-Thiobis-(4,6-dichlorophenol)

chemische Verbindung

Chemical data

Formula: C12H6Cl4O2S
Molecular weight: 356 g/mol
IUPAC name: 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
SMILES: C1=C(C=C(C(=C1SC2=C(C(=CC(=C2)Cl)Cl)O)O)Cl)Cl
InChIKey: JFIOVJDNOJYLKP-UHFFFAOYSA-N
XLogP: 5.8
Polar surface area: 65.8 Å²
H-bond donors: 2
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
Indications: acne, Helminthiasis

via ChEMBL · EBI

Research

325 papers

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis.Cell death discovery · 2024
Bithionol Restores Sensitivity of Multidrug-Resistant Gram-Negative Bacteria to Colistin with Antimicrobial and Anti-biofilm Effects.ACS infectious diseases · 2023
The potential target of bithionol against Staphylococcus aureus: design, synthesis and application of biotinylated probes Bio-A2.The Journal of antibiotics · 2023
Antimicrobial and Antibiofilm Effects of Bithionol against Mycobacterium abscessus.Antibiotics (Basel, Switzerland) · 2024
Bithionol is ineffective in a mouse model of S. aureus implant-associated osteomyelitis despite potent in vitro activity.Scientific reports · 2025

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 353.88426115199997
Has use: medication

Show 4 more facts

chemical formula: C₁₂H₆Cl₄O₂S
World Health Organisation international non-proprietary name: bithionol
canonical SMILES: C1=C(C=C(C(=C1Cl)O)SC2=CC(=CC(=C2O)Cl)Cl)Cl
Commons category: Bithionol

Sources (2)

via Wikidata · CC0

Available in 8 languages

via Wikidata sitelinks · CC0